not angka pianika lagu melayu selayang pandang added by usersGames and other applications provided to a computing device via a network have become increasingly popular. Such games and applications provide interactive experiences for users that would not be available via traditional media. For example, with the increasing availability and decreasing costs of Internet connectivity, many people enjoy online gaming and other interactive experiences, which are otherwise difficult to access or unavailable.
A user can access these games and other applications via a computing device (e.g., computer, mobile phone, tablet computer, etc.), which may be coupled to a network (e.g., the Internet). The user can view various menus and other interface content via the display device of the computing device.
The figures are not to scale. Wherever possible, the same reference numbers will be used throughout the drawing(s) and accompanying written description to refer to the same or like parts.Development of new potential therapeutics for systemic sclerosis has been complicated by the fact that tissue specimens are not easily accessible and little is known of the early dermal pathology. A major challenge is to develop novel MRI and BOLD imaging technologies that will allow us to noninvasively image the skin of patients with systemic sclerosis. The project proposed in this application is to provide novel agent that will bind to macrophages that have extravasated into the skin of patients with systemic sclerosis. The anti- macrophage monoclonal antibody (mAb) 9E3 will be constructed to promote macrophage phagocytosis of the probe. The 9E3 mAb will be used to produce biocompatible 9E3-dextran probes for systemic sclerosis tissue and the probes will be injected into the cutaneous tissue of the extremities of SSc patients and imaging will be done using MRI and BOLD scanning. Our hypothesis is that 9E3-dextran targets macrophages in SSc by binding to CD68 macrophages (the receptors for 9E3 are on late endosomes) and that this binding contributes to the pathophysiology of SSc. This is an independent proposal of a collaboration between clinical imaging scientists and molecular imaging scientists at Tufts University to design and test new imaging agents. Successful implementation of the project would lead to noninvasive high-resolution imaging of macrophage phagocytosis in the skin of SSc patients. Although this 0b46394aab