On-Going Ð’ Page 12 Of 104 Ð’ FAP NATION
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The safety, tolerability, and nontoxicity of curcumin at high doses are well established by human clinical trials (3,4). Our own group found that curcumin at 8 g/day in combination with gemcitabine was safe and well-tolerated in patients with pancreatic cancer (11,12). The clinical trials conducted thus far have indicated the therapeutic potential of curcumin against a wide range of human diseases. It has also shown protection against hepatic conditions, chronic arsenic exposure, and alcohol intoxication (Fig. 1b). In these clinical trials, curcumin has been used either alone or in combination with other agents such as quercetin, gemcitabine, piperine, docetaxel, soy isoflavones, bioperine, sulfasalazine, mesalamine, prednisone, lactoferrin, N-acetylcysteine, and pantoprazole (Table I).
Curcumin has also demonstrated potential for the prevention and treatment of CRC in combination with other agents. Familial adenomatous polyposis (FAP) is an autosomal-dominant disorder characterized by hundreds of colorectal adenomas that eventually develop into CRC. Although nonsteroidal anti-inflammatory drugs (NSAIDs) and COX-2 inhibitors have been shown to reduce the adenomas in this syndrome, these drugs produce numerous adverse effects. One study evaluated whether the combination of curcumin and quercetin could suppress adenomas in patients with FAP (16). Five patients with FAP who had undergone prior colectomy received combinations of curcumin (480 mg) and quercetin (20 mg) orally three times a day, and the number and size of polyps were assessed at baseline and after therapy. The number and size of polyps had decreased after 6 months of combination treatment without any appreciable toxicity in the five patients (Fig. 2a). Although the combinations seemed to reduce the adenomas, randomized controlled trials are needed to further validate these findings (16).
Using geolocation methods, each piece of equipment can be pinpointed to its exact location coordinates using a combination of sources. This includes using satellite imagery of the area and matching it with landmarks visible in the media images.
A variety of Russian manufactured arms and munitions not used by the Ukrainian military have appeared in the hands of separatists groups, including shoulder launched surface-to-air missiles (MANPADS), various types of rocket launchers, anti-tank guided missiles (ATGMs), landmines, and various small arms.38Jonathan Ferguson and N.R. Jenzen-Jones, Raising Red Flags: An Examination of Arms & Munitions in the Ongoing Conflict in Ukraine, 2014 (Australia: Armament Research Services (ARES), November 18, 2014), -%20Raising%20Red%20Flags.pdf.
During key offensives, Russian forces in Ukraine have received cover from shelling from Russian territory. In the summer of 2014, the Ukrainian Border Service and the National Security and Defense Council reported more than 120 artillery attacks from Russia.76The Ukrainian government reports were collected by Bellingcat in a database: -kZSkwlfY8GnikeJdbCOh3RQ/editusp=sharing. Despite Russian government denials, with a combination of satellite data, crater analysis, and open source materials, one can establish that many of these attacks originated in Russia and not in the separatist controlled areas of Ukraine. 59ce067264
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